On 14 June 2009 Keegan made her radio debut co-hosting the Bbc Radio 1  programme The Official Chart with Reggie Yates

Keegan was on the cover of FHM Magazine in January 2011, and placed #30 and #26 in the FHM 100 Sexiest Women poll for 2010 and 2011 respectively.
In late 2007, in only her second-ever audition, she was offered the chance to play the part of Tina in Coronation Street and accepted the role and she still plays this character to present day.​

Keegan dated Hollyoaks actor Anthony Quinlan from 2006 to 2008 and model Brad Howard from 2008 to 2010.In December 2010 she began seeing Max George from boyband The Wanted,  and the two became engaged on her birthday.
However, in April 2012 Keegan confirmed that the engagement was off after George stated on live radio they were no longer engaged. On the 21st July 2012 it was reported that she and Max are no longer together, citing busy schedules as the main reason for the end of their relationship. However, they intend to remain close friends.

Keegan claims to enjoy shopping, acting, singing, and dancing.​